RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
SERPINE1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
AEC purification; A549 cell wounding assay; Bleomycin exposure etc.
Target
NA
Pathway
NA
PubMed ID
Title
Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectin
Year
2004
Function
Accentuated impairment of plasminogen activation through PAI-1 overexpression leads to exuberant fibrosis after lung injury.